Figure 4.

Gene product interaction network of “Interferon-γ” gene set—an up-regulated pathway in subcutaneous fat of OSA subjects relative to those without OSA. A number of the most highly connected nodes (known as hubs) have been labeled, including interferon-γ (IFNG), FAS, STAT1, STAT3, CASP3, CASP8, and TNFSF10. Note that the interactions among these densely connected nodes (shown as green lines) capture the majority of the network’s overall connectivity (green and gray lines). These hubs represent key drivers of OSA-induced activation of interferon-γ signaling in subcutaneous adipose tissue. Full list of network nodes is provided in Supplementary Table S5.