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. 2019 Dec 13;43(6):zsz302. doi: 10.1093/sleep/zsz302

Figure 2.

Figure 2.

Lemborexant increased transitions into NREM and REM sleep. Amounts of wake, NREM sleep, REM sleep, and cataplexy as a percentage of time in WT (A) and OXKO (A′) mice across the 6 h after lemborexant administration. Lemborexant increased the number of wake, NREM sleep, and REM sleep bouts in WT mice (B) but not in OXKO mice (B′). Lemborexant severely shortened the duration of wake bouts in WT mice (C). Time-weighted frequency histograms highlight the shift toward short wake bouts in WT mice (D). * p < 0.05, ** p < 0.01 compared to vehicle day.