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. 2020 Mar 4;7(2):ENEURO.0453-19.2020. doi: 10.1523/ENEURO.0453-19.2020

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Copyright © 2020 Gill and Hansel

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — The role of PKA and CK2 in regulating SK2 channels in intrinsic plasticity. A, Example traces for cells treated with H89, a PKA inhibitor that was present in the bath for the duration of the experiment. B, Time graph for changes in spiking relative to baseline. Either somatic depolarization or oxo-m was applied from minute 5 to 10. C, Example traces for cells treated with TBB, a CK2 inhibitor that was present in the bath for the duration of the experiment. D, Time graph for changes in spiking relative to baseline. Either somatic depolarization or oxo-m was applied from minute 5 to 10. E, Bar graph for depolarization-induced changes in spiking relative to baseline. Both H89 and TBB bath application prevented intrinsic plasticity. F, Bar graph for oxo-m-induced changes in spiking relative to baseline. H89, but not TBB, prevented intrinsic plasticity; *p < 0.05. n.s. = nonsignificant.