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. 2020 Jun 9;7(3):ENEURO.0500-19.2020. doi: 10.1523/ENEURO.0500-19.2020

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Copyright © 2020 Lau et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Overall patterns of PNN density across medial-lateral axis is preserved in Mecp2^Het. (A) Similar to NW-SW in Figure 3, NH and SH displayed significant increase of PNN density in lateral sections compared to the medial sections of the same condition (grey p value denotes NH: n = 23 images for medial, 27 images for lateral; black p value denotes SH: n = 36 images for medial, 25 images for lateral). Along the sub regions encompassing the medial-lateral axis, there was no significant difference between NH and SH, represented by the light blue lines (medial: n = 42 images for NH, 59 images for SH; middle: n = 37 images for NH, 55 images for SH; lateral: n = 44 images for NH, 48 images for SH). N = 5–22 images per map coordinate. (B) Within hemispheres of NH, statistical analysis of the lateral sections of the right (NH-R, black p value) and the left (NH-L, grey p value) showed significantly higher PNN density than their medial sections (NH-L: n = 9 images for medial, 16 images for lateral; NH-R: n = 14 images for medial, 11 images for lateral). There was no significant difference between hemispheres along the medial-lateral axis (medial: n = 23 images for L, 19 images for R; middle: n = 17 images for L, 20 images for R; lateral: n = 29 images for L, 15 images for R). (C) A different pattern of hemisphere-specific differences was observed in SH. SH-R did not display significant difference between medial and lateral sections, while SH-L did (grey p value denotes SH-L: n = 9 images in lateral, n = 20 images for medial; black p value denotes SH-R: n = 16 images for both lateral and medial). Statistical comparison between hemispheres revealed dynamic differences across medial-lateral axis, with SH-R had significantly higher PNN density than SH-L in medial and middle regions, while SH-L had significantly higher PNN density in the lateral regions (light blue lines; medial: n = 29 images for L, 30 images for R; middle: n = 31 images for L, 24 images for R; lateral: n = 20 images for L, 28 images for R). For A–C, lines represent mean values. Each dot represents PNN density in an individual section. Mann-Whitney test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. = not significant, 5 mice per condition. For B–C, n = 1–12 images per map coordinate.