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. Author manuscript; available in PMC: 2020 Jun 15.
Published in final edited form as: Cytokine Growth Factor Rev. 2009 Aug 4;20(4):305–317. doi: 10.1016/j.cytogfr.2009.07.002

Table 2.

Summary of data indicating a protective role for TGF-β3 in tumourigenesis.

  • Shares tumour suppressive role early in disease with TGF-β and TGF-β2

  • Increased TGF-β3 expression associated with good prognosis in breast cancer

  • TGF-β3 is a key determinant in parity-induced protection against breast cancer

  • Increased TGF-β3 expression associated with oral contraceptive protection against ovarian cancer

  • TGF-β3 expression associated with inhibition of metastases at late stage of colon cancer

  • Decreased TGF-β3 expression observed in the epithelium overlying primary melanomas

  • Decreased TGF-β3 expression observed in prostate cancer biopsies