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. 2020 Jun 10;13:5375–5386. doi: 10.2147/OTT.S242342

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© 2020 Deng et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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miR-124-3p.1 targets CAV1 in ovarian cancer. (A) Putative binding site paired with miR-124-3p.1 at the 3ʹ UTR of CAV1 mRNA. (B) Protein level of CAV1 in human normal ovarian surface epithelial cell line HOSEpiC and human ovarian cancer cell lines SKOV3 and A2780. (C) Effect of miR-124-3p.1 transfection on decreasing the CAV1 expression in SKOV3 and A2780 cells. (D) After co-transfection with pMIR-REPORT, pRL-TK renilla plasmid and miR-124-3p.1 for 48 h, luciferase activities in SKOV3 and A2780 cells were measured by using dual luciferase assay system.

Notes: Data were expressed as mean±SD. *P<0.05 vs NCO group.

Abbreviations: miR-124-3p.1, microRNA-124-3p.1; CAV1, caveolin-1; mRNA, messenger RNA.