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. 2020 Jun 10;13:5375–5386. doi: 10.2147/OTT.S242342

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© 2020 Deng et al.

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Role of miR-124-3p.1/CAV1 axis in carboplatin-induced cytotoxicity against ovarian cancer. (A) Effect of miR-124-3p.1 and CAV1 plasmid transfection on changing the CAV1 expression in SKOV3 and A2780 cells. (B) Effect of CAV1 plasmid transfection on improving the cell viability of miR-124-3p.1-transfected SKOV3 and A2780 cells which were treated with carboplatin (0.5 μM). (C) Effect of CAV1 siRNA transfection on changing the CAV1 expression in SKOV3 and A2780 cells. (D) Effect of CAV1 siRNA transfection on enhancing the carboplatin-induced (0.5 μM) cytotoxicity against SKOV3 and A2780 cells.

Notes: Data were expressed as mean±SD. *P<0.05 vs carboplatin + NCO group. ^#P<0.05 vs carboplatin + miR-124-3p.1 group.

Abbreviations: miR-124-3p.1, microRNA-124-3p.1; CAV1, caveolin-1; siRNA, small interfering RNA.