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. 2020 Jun 10;13:5375–5386. doi: 10.2147/OTT.S242342

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© 2020 Deng et al.

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Schema of the predicted mechanisms implicated in SKOV3 and A2780 cells response to carboplatin and miR-124-3p.1. miR-124-3p.1 inhibits CAV1 expression and thus inhibits the phosphorylation of AKT and Bad. High level of dephosphorylated Bad then inhibits the function of Bcl-xl and thus made the Bax free. Under the apoptosis signals dependent on the carboplatin treatment, the free Bax conjugates to Bak and induces mitochondrial outer membrane (MOM) permeability and decrease of mitochondrial membrane potential (Δφ). As a result, cytochrome c is released from the mitochondria into the cytosol. Subsequently, the effector caspases are triggered and the final apoptosis has occurred.

Abbreviations: miR-124-3p.1, microRNA-124-3p.1; CAV1, caveolin-1; AKT, threonine protein kinase; Bad, BCL2 associated agonist of cell death; Bcl-xl, B-cell lymphoma-extra large; Bax, BCL2 associated X; Bak, BCL2 antagonist/killer; MOM, mitochondrial outer membrane; Δφ, mitochondrial membrane potential.