Table 2.
Stratified results for different empirical prescribing. Unadjusted analysis
| Monotherapy penicillin G/V (n = 335) | Combination penicillin G and gentamicin (n = 149) | Other antibiotics (n = 167) | p-value* | |
|---|---|---|---|---|
| n (%) | n (%) | n (%) | ||
| Age, years | ||||
| Mean | 72.8 | 70.8 | 70.4 | 0.29 |
| Gender, female | 150 (44.8) | 67 (45.0) | 86 (51.5) | 0.33 |
| Comorbidities | ||||
| COPD | 94 (28.1) | 44 (29.5) | 67 (40.1) | 0.02 |
| Heart failure | 73 (21.8) | 26 (17.5) | 41 (24.6) | 0.30 |
| Diabetes mellitus I or II | 50 (14.9) | 13 (8.7) | 22 (13.2) | 0.17 |
| Nursing home resident | 27 (8.1) | 22 (14.8) | 21 (12.6) | 0.06 |
| Penicillin allergy | 8 (2.4) | 2 (1.3) | 60 (35.9) | 0.00 |
| CRB-65 | 0.11 | |||
| 0 | 57 (17.0) | 23 (15.4) | 30 (18.0) | |
| 1 | 127 (37.9) | 38 (25.5) | 60 (35.9) | |
| 2 | 87 (26.0) | 46 (30.9) | 46 (27.5) | |
| 3 | 15 (4.5) | 17 (11.4) | 11 (6.6) | |
| 4 | 2 (0.6) | 2 (1.3) | 2 (1.2) | |
| Missing data | 47 (14.0) | 23 (15.4) | 18 (10.8) | |
| Antibiotic use pre-hospitalization | 64 (19.1) | 40 (26.9) | 67 (40.1) | 0.00 |
| Treatment amended within 3 days | 56 (16.7) | 25 (16.8) | 25 (15.0) | 0.87 |
| IV treatment duration, mean (days) | 3.4 | 4.1 | 4.1 | 0.01 |
| Total treatment duration, mean (days) | 11.4 | 12.3 | 11.3 | 0.04 |
| Clinical outcomes | ||||
| 30-day readmission | 38 (11.6) | 19 (13.4) | 33 (20.8) | 0.02 |
| Length of stay (mean) | 5.1 | 5.8 | 5.0 | 0.20 |
| 30-day mortality | 20 (6.0) | 11 (7.4) | 13 (7.8) | 0.70 |
CRB-65 Confusion, respiration, blood pressure and age ≥ 65y, COPD Chronic obstructive pulmonary disease, IV intravenous
*Categorical data analyzed using Pearson’s χ2-test and continuous data using ANOVA test