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. 2020 Jun 15;20:239. doi: 10.1186/s12935-020-01309-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — m⁶A-associated mechanism in melanoma. a Top 10 GO terms for RNA processing. b Network of all genes identified with the a String tool. c Venn diagram of genes identified with different analysis methods to determine the key genes in melanoma. d Network and rank scores of 31 hub genes found in the results from all four methods in (c). e Heat map of genes that had a significant relationship with YTHDF1 or HNRNPA2B1. f Scatter plots of expression of YTHDF1 and HNRNPA2B1 and all genes in (e) and their associations. g Pathway or GO terms of the critical genes in melanoma and their relationship with YTHDF1 or HNRNPA2B1. MCC, maximal clique centrality; MNC, maximum neighborhood component; EPC, edge percolated component. * P < 0.05, δ P < 0.01, Ф P < 0.001, Δ P < 0.0001

Fig. 4 — m⁶A-associated mechanism in melanoma. a Top 10 GO terms for RNA processing. b Network of all genes identified with the a String tool. c Venn diagram of genes identified with different analysis methods to determine the key genes in melanoma. d Network and rank scores of 31 hub genes found in the results from all four methods in (c). e Heat map of genes that had a significant relationship with YTHDF1 or HNRNPA2B1. f Scatter plots of expression of YTHDF1 and HNRNPA2B1 and all genes in (e) and their associations. g Pathway or GO terms of the critical genes in melanoma and their relationship with YTHDF1 or HNRNPA2B1. MCC, maximal clique centrality; MNC, maximum neighborhood component; EPC, edge percolated component. * P < 0.05, δ P < 0.01, Ф P < 0.001, Δ P < 0.0001