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(a) Metabolic stability in rat liver microsomes. 1 was barely metabolized by microsomes. 4b and 5a were more stable than imipramine. (b) Plasma stability assay (rat). 5a and 4b were more stable than 1 in rat plasma. Samples were analyzed by LC–MS at the time points indicated. Plotted data represent standard corrected % peak areas of samples at t = 0 min and are given as mean ± SEM (n ≥ 3).
