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. 2020 Apr 10;11(6):1175–1184. doi: 10.1021/acsmedchemlett.0c00029

Figure 1.

Figure 1

(a) Chemical structures of AcCoA, CoA, literature reported bisubstrate inhibitor (1), and its truncated analog: des-A (2). (b) Cocrystal structure of 1 bound to Naa50 (2.3 Å, PDB ID 6WF3). Compound 1 is drawn in orange stick representation and spans the binding pocket, from the cofactor binding site on the left to the peptide binding site on the right. Residues that form hydrogen bonds with the ligand (dashed lines) are drawn as green sticks. Hydrogen bonds are drawn as dashed lines. Protein Cα trace is shown in gray.