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. 2020 May 8;11(6):1287–1291. doi: 10.1021/acsmedchemlett.0c00119

Table 1. SAR of the Fused Benzene Ring.

graphic file with name ml0c00119_0006.jpg

entry compound R1 IC50 (μM)a
1 4a F 12.02 ± 0.63
2 5a F 0.35 ± 0.03
3 5b Cl 0.08 ± 0.00
4 5c CH3 1.10 ± 0.11
5 5d OCH3 5.16 ± 0.62
6 6a F 4.67 ± 0.42
7 6b Cl 0.87 ± 0.01
8 6c CH3 >25
9 6d OCH3 >25
10 7a F 0.43 ± 0.04
11 7b Cl 0.24 ± 0.11
12 7c CH3 1.56 ± 0.07
13 7d OCH3 2.10 ± 0.61
a

Data are presented as mean ± standard deviation (SD) (n = 3). SAR, structure–activity relationship.