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(Top) Examples of reported β-weighted PI3K inhibitors and docked pose of TGX-221-R in a PI3Kβ homology model built from the cocrystal structure of (P)-19 bound to PI3Kδ (pdb: 6DGT).19 (Bottom) Biochemical potency and selectivity of a novel PI3Kβ chemotype compared to other reported inhibitors.
