Table 4. Profiles of the Single Atropisomers.

^aSee footnotes a and b of Table 2.

^bAnalytical methods indicate that both purified atropisomers are free of the other by the limit of detection of our technology (>98% ee). The (M)-atropisomer may be completely devoid of PI3Kβ activity, but a 1% impurity of (P)-atropisomer would result in IC₅₀ values between 200 and 1,000 nM.

^cDetermined from human hepatocytes.

^dUnits: 106 cm/s.