. 2020 Apr 13;11(6):1236–1243. doi: 10.1021/acsmedchemlett.0c00095

Table 5. Activity against AKT1 Ser473 Phosphorylation in PTEN-Deficient Tumor Cell Lines.

Cell line	GSK2636771	(P)-14	(P)-19
PC3 EC₅₀ (nM)^a	23	12	9
LNCaP C4-2 EC₅₀ (nM)^a	42	24	15
LNCaP EC₅₀ (nM)^a	178	31	53
MDA-MB-415 EC₅₀ (nM)^a	40	15	12
ZR-75-1 EC₅₀ (nM)^a	28	5	6

Data determined from the ratio of Units pAKT1 Ser473 per nanogram total AKT1.