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Targeted cellular inhibition of CPS1 activity. Inhibition of urea production from primary human hepatocytes by 25, 26, 27, and 28 is shown. Primary human hepatocytes were incubated with 10 mM NH4Cl in the presence of compound at the indicated concentration. Urea secreted into the medium was measured after 16 h. The data are provided as a representative graph. Replicate experiments yielded similar results.
