Table 2. Initial Amide SAR for the (2R,6R)-2,6-Dimethylpiperazine Core.

^aIC₅₀ values were determined in a biochemical assay measuring ADP formation from CPS1 in the presence of the inhibitor. See the Supporting Information for methods. The reported IC₅₀ values are averages of at least two experimental replicates (N = 2).