Table 6. Pharmacokinetic Profiles of Compound 20.
| species | route | dose (mg/kg) | Cmaxa (ng/mL) | Vssa (mL/kg) | T1/2a (h) | CLa (mL/min/kg) | Fb (%) |
|---|---|---|---|---|---|---|---|
| mouse | po | 1 | 124 ± 49 | 5.4 ± 2.1 | |||
| rat | iv | 0.3 | 1474 ± 153 | 3.4 ± 0.9 | 8.2 ± 2.3 | ||
| po | 1 | 261 ± 107 | 2.5 ± 0.3 | 51.6 | |||
| dog | iv | 0.3 | 1863 ± 878 | 8.9 ± 5.3 | 4.7 ± 0.7 | ||
| po | 1 | 1670 ± 610 | 5.9 ± 2.0 | 71.1 | |||
| monkey | iv | 0.3 | 2275 ± 235 | 7.9 ± 1.0 | 5.8 ± 0.6 | ||
| po | 1 | 63 ± 38 | NC | 30.8 |
a
The values are expressed as the mean ± standard deviation (n = 3), NC = not calculated.
b
F (%) was calculated using the mean of AUC (po) and the mean of AUC (iv).