Table 1. EC50 Values (μM) for Host Cells and Intracellular T. cruzi Forms.
Sample | EC50_T. cruzi | EC50_host | S.I.a |
---|---|---|---|
BNZ | 2.2 ± 0.4 | >40 | >18 |
40 | 2.4 ± 0.4 | 8.5 ± 1.9 | 3.5 |
15 | 2.4 ± 0.3 | 7.5 ± 0.6 | 3.1 |
39 | 3.2 ± 1 | 5.6 ± 1.6 | 1.8 |
6 | 3.5 ± 0.4 | 8.4 ± 1.8 | 2.4 |
32 | 4.2 ± 0.5 | 12.3 ± 1.8 | 2.9 |
3 | 6.4 ± 2 | 13 ± 2 | 2.0 |
12 | 8.5 ± 1.5 | 14.7 ± 4.2 | 1.7 |
13 | 16.7 ± 4.2 | 54 ± 3.3 | 3.2 |
S.I. = selectivity index calculated as EC50_host/EC50_T. cruzi. Mean and standard deviation for 3 independent experiments.