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. 2020 Apr 27;11(6):1250–1256. doi: 10.1021/acsmedchemlett.0c00106

Table 1. EC50 Values (μM) for Host Cells and Intracellular T. cruzi Forms.

Sample EC50_T. cruzi EC50_host S.I.a
BNZ 2.2 ± 0.4 >40 >18
40 2.4 ± 0.4 8.5 ± 1.9 3.5
15 2.4 ± 0.3 7.5 ± 0.6 3.1
39 3.2 ± 1 5.6 ± 1.6 1.8
6 3.5 ± 0.4 8.4 ± 1.8 2.4
32 4.2 ± 0.5 12.3 ± 1.8 2.9
3 6.4 ± 2 13 ± 2 2.0
12 8.5 ± 1.5 14.7 ± 4.2 1.7
13 16.7 ± 4.2 54 ± 3.3 3.2
a

S.I. = selectivity index calculated as EC50_host/EC50_T. cruzi. Mean and standard deviation for 3 independent experiments.