Scheme 1. Synthesis of Aryl Adamantane Carboxamides.
Reagents and conditions: (i) Br2, Fe, 0 °C for 30 min, then rt, 8 h; (ii) AlCl3, Ar–H, reflux, 6 h; (iii) R3R4NH, EDC hydrochloride, HOAt, DIEA, DCM, rt, 12 h; (iv) TFA, DCM, rt, 2 h.
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