Figure 2.
Validation of noninvasive assessment of CK activity. A, Representative spectra constituting the triple repetition time saturation transfer method for estimating CK kf in a cardiac voxel of interest. B, Absolute CK activity measured from left ventricular biopsy correlated with CK capacity estimated by total creatine×kf (adjusted for supine scanning). Dante (Delays Alternating with Nutation for Tailored Excitation) is the pulse sequence used for selective saturation of γATP or the control position methods to assess, and in vivo CK capacity, which has been estimated as CK total activity×[total creatine]. CK indicates creatine kinase; 2,3-DPG, 2,3-diphosphoglycerate; PCr, phosphocreatine; and TR, repetition time.