Table 6.

Proposed organ dysfunction (O) scoring criteria. Each evidence of organ dysfunction equals to 1 point

Dysfunction	Criteria
Renal	Creatinine> 1.64 mg/dl; Creatinine> 1.64 mg/dl and Urea> 56 mg/dl
Cardiovascular	Hypotension requiring vasopressor drugs administration
Respiratory	Need for oxygen or ventilation supply, ARDS
Hepatic	Bile acid> 25 μmol/L (post-prandial) and/or Bilirubin> 0,41; ALT> 130 U/L 37 °C e ALP > 337 U/L 37 °C; Albumin < 2.1 g/dl
Coagulation alterations	Platelets≤100.000/μL

Legend: mg/dl (milligram per decilitre); g/dl (gram per decilitre); ARDS (Acute Respiratory Distress Syndrome); ALT (alanine aminotransferase); ALP (alkaline phosphatase); U/L 37 °C (units per litre at 37 degrees Celsius); μL (microliter)

The considered values correspond to the upper limit considered by VTH Clinical Analysis Laboratory (where all the blood samples were analysed)