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. Author manuscript; available in PMC: 2020 Jun 15.
Published in final edited form as: Neuropharmacology. 2017 Oct 6;134(Pt A):149–157. doi: 10.1016/j.neuropharm.2017.10.006

Table 1:

IC50 values for inhibition of transporter-mediated uptake by FPM isomers in HEK293 cells. Values are given as mean ± SEM obtained from nonlinear curve fits obtained from n=3 independent experiments, performed in triplicate (data shown in Figure 2). DAT/SERT ratio is expressed as 1/(DAT IC50) divided by 1/(SERT IC50); higher values indicate greater selectivity for DAT. NET/SERT ratio is expressed as 1/(NET IC50) divided by 1/(SERT IC50); higher values indicate greater selectivity for NET. DAT/NET ratio is expressed as 1/(DAT IC50) divided by 1/(NET IC50); higher numbers indicate greater DAT-selectivity.

IC50 (µM)
DAT NET SERT DAT / SERT ratio NET / SERT ratio DAT / NET ratio
2-FPM 1.33 ± 0.09 1.29 ± 0.03 454 ± 15.4 340.1 351.4 0.97
3-FPM 1.16 ± 0.29 1.51 ± 0.17 111.65 ± 13.08 96.4 73.7 1.31
4-FPM 2.14 ± 0.39 2.05 ± 0.28 88.09 ± 1.83 41.2 42.9 0.96