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. Author manuscript; available in PMC: 2020 Jun 15.
Published in final edited form as: Neuropharmacology. 2017 Oct 6;134(Pt A):149–157. doi: 10.1016/j.neuropharm.2017.10.006

Table 2:

EC50 values for transporter-mediated release by FPM isomers in rat brain synaptosomes. Values are given as mean ± SEM obtained from nonlinear curve fits as shown in Figure 4. DAT/SERT ratio is expressed as 1/(DAT EC50) divided by 1/(SERT EC50); higher values indicate greater selectivity for DAT. NET/SERT ratio is expressed as 1/(NET EC50) divided by 1/(SERT EC50); higher values indicate greater selectivity for NET. DAT/NET ratio is expressed as 1/(DAT EC50) divided by 1/(NET EC50); higher numbers indicate greater DAT-selectivity.

EC50 (nM)
DAT NET SERT DAT / SERT ratio NET / SERT ratio DAT / NET ratio
2-FPM 112 ± 10 28 ± 3 4808 ± 1265 43 172 0.25
3-FPM 60 ± 4 17 ± 4 1269 ± 207 21 75 0.28
4-FPM 191 ± 17 58 ± 7 1895 ± 424 10 33 0.30