FIGURE 6.

H3K9me3‐landscaped and synaptic function‐related transcriptome are deregulated in AD. (a) The expression of BDNF, GABBR1, GABRA2, GPRASP1, SYT12, and NCALD were down‐regulated in AD patients (N = 28) compared to normal control subjects (N = 24). Significantly different at *p < .05; **p < .001. (b) The protein levels of BDNF were reduced in AD patients (N = 5) compared to normal control subjects (N = 5). (c) BDNF immunoreactivity is reduced in neurofilament heavy chain (NF‐H)‐positive cortical neuron of AD patient. Scale bars (white): 5 µm. (d) A scheme showing that increased H3K9me3 levels and heterochromatin condensation contribute to synaptic deregulation in AD by repressing the expression of synaptic function‐related genes (such as BDNF and GABBR1)