Figure 1.

Pedigree overview of the data structure. This figure illustrates the two approaches: (1) the original approach and (2) the combined approach. The original approach refers to the case and control group based on the F1 IPs where cases died at 80 years or older and controls died between 40 and 59 years (panel a). Panel b shows a pedigree of the data from the perspective of F3 children (combined approach). The combined approach refers to the dataset where we combined the cases and controls from the original approach and constructed a new case and control group in the F3 descendants. To this end, F3 descendants with ≥30% long‐lived ancestors were labeled as family cases and those without long‐lived ancestors as family controls. F3 spouses were left out of this figure, but this group was used to confirm a genetic enrichment in the F3 descendants