Table 1.
Overview study sample for groups in all generations based on the proband and F3 perspective
| Role | Number | Deceased (%) | Alive (%) | Female (%) | Range birth cohort | Mean age (sd) | Median age (sd) | missing_age (%) |
|---|---|---|---|---|---|---|---|---|
| Cases (original approach) | ||||||||
| F1 IPs | 884 | 884 (100) | 0 (0) | 422 (50) | 1860–1875 | 85.79 (4.59) | 84.99 (4.95) | 0 (0) |
| F2 descendants | 4,916 | 4,405 (90) | 11 (1) | 2,435 (50) | 1879–1941 | 63.04 (31.11) | 75.51 (17.72) | 500 (9) |
| F2 spouses | 3,899 | 1,500 (38) | 16 (1) | 1504 (38) | 1873–1934 | 76.2 (15.09) | 78.78 (12.83) | 2,383 (61) |
| F3 descendants | 9,910 | 4,869 (49) | 4,146 (42) | 4,733 (48) | 1901–1973 | 70.35 (19.54) | 74.77 (11.38) | 895 (9) |
| F3 spouses | 3,431 | 1,289 (38) | 792 (23) | 1963 (57) | 1900–1959 | 77.14 (11.31) | 79.25 (10.1) | 1,350 (39) |
| F4 descendants a | 9,001 | 746 (8) | 7,172 (80) | 3,937 (44) | 1922–1995 | 57.7 (10.68) | 58.21 (9) | 1,083 (12) |
| Controls (original approach) | ||||||||
| F1 IPs | 442 | 442 (100) | 0 (0) | 214 (48) | 1860–1875 | 51.71 (5.71) | 52.88 (6.21) | 0 (0) |
| F2 descendants | 2,488 | 2,202 (89) | 1 (<1) | 1,217 (49) | 1881–1925 | 58.17 (32.49) | 71.72 (21.37) | 285 (11) |
| F2 spouses | 1,877 | 690 (37) | 7 (<1) | 734 (39) | 1875–1935 | 76.02 (14.77) | 78.34 (13.76) | 1,180 (63) |
| F3 descendants | 4,761 | 2,540 (53) | 1813 (38) | 2,265 (48) | 1904–1966 | 69.39 (20.38) | 74.49 (11.36) | 408 (9) |
| F3 spouses | 1,778 | 721 (41) | 376 (21) | 972 (55) | 1893–1965 | 76.54 (11.5) | 78.66 (10.47) | 681 (38) |
| F4 descendants a | 4,710 | 387 (8) | 3,744 (80) | 2099 (45) | 1871–1992 | 57.72 (11.17) | 58.37 (9.35) | 579 (12) |
| F3 perspective (combined approach) | ||||||||
| F3 descendants | 14,671 | 7,409 (51) | 5,959 (41) | 6,998 (48) | 1901–1973 | 70.03 (19.82) | 74.68 (11.38) | 1,303 (8) |
| F3 spouses | 5,209 | 2,010 (38) | 1,168 (22) | 2,935 (55) | 1893–1965 | 76.93 (11.38) | 79.07 (10.24) | 2,031 (40) |
| F2 parents | 9,728 | 6,139 (63) | 23 (1) | 4,137 (43) | 1873–1935 | 76.8 (13.4) | 78.9 (12.31) | 3,566 (36) |
| F2 aunts and uncles | 7,036 | 6,382 (91) | 10 (1) | 3,456 (49) | 1879–1941 | 61.81 (31.47) | 74.4 (18.67) | 644 (8) |
| F1 grandparents | 1,181 | 1,181 (100) | 0 (0) | 560 (47) | 1860–1875 | 74.88 (16.6) | 81.94 (9.72) | 0 (0) |
The Cases and Controls rows provide an overview of the groups of persons from the original case/control perspective of the data, described as the first study phase (original approach). The F3 perspective rows provide an overview of the groups of persons from the perspective of F3 descendants, described as the second study phase (combined approach). Mean and missing age refer to an unknown age at death or an unknown age at last observation. For the F0 and F1 groups, we assume everyone is dead because the birth cohorts date back further than 120 years. From the F2 generations, we requested Personal Records Data indicating if a person was still alive or not and if not, what the date of death was. The F1 IPs are the focal persons in the pedigrees as they are selected to be 80 years or older (cases) or to have died between 40 and 59 years (controls).
Indicates that the group is excluded for this study, and sd refers to standard deviation. Please note that the F3 perspective (second study phase, combined approach) is used to identify a new group of cases and controls based on the LRC score and are referred to as family cases and family controls.