Table 4.

Standardized mortality ratio for different F3 descendant groups

Group	SMR	N
Cases
F3 descendant with at least one long‐lived grandparent	0.86 (95% CI = 0.83–0.89)	4,986
F3 descendant with at least one long‐lived parent	0.84 (95% CI = 0.76–0.92)	852
F3 descendant with ≥30% long‐lived ancestors (LRC ≥ 30%)	0.74 (95% CI = 0.70–0.78)	2,304
F3 descendant with ≥50% long‐lived ancestors (LRC ≥ 50%)	0.62 (95% CI = 0.55–0.96)	565
Controls
F3 descendant with grandparent who died between 40 and 59 years	0.96 (95% CI = 0.93–1.00)	4,353
F3 descendant with no long‐lived ancestors (LRC = 0)	0.97 (95% CI = 0.93–1.01)	3,782

Long‐lived is defined as belonging to the top 10% survivors of their birth cohort. Note that the group size (N) reflects only those with a known age at death as this was necessary to estimate a standardized mortality ratio.