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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: J Org Chem. 2020 Apr 20;85(9):6044–6059. doi: 10.1021/acs.joc.0c00535

Table 5.

Reaction Scope with Different Michael Acceptorsa

graphic file with name nihms-1593696-t0067.jpg
a

Yields are reported for isolated and purified products. Yield values reflect the average of duplicate trials.

b

Reaction for 5 days at 70 °C.

c

Diastereomeric ratio determined by crude 1H NMR spectroscopy.

d

Initial 24 h incubation neat at 40 °C. Then C6H6 and DIPEA were added for an additional 24 h at 40 °C.

e

The reaction was heated to 90 °C.