Fig. 3.

SAN HF cells demonstrate increased sensitivity to negative chronotropic effects of adenosine

Representative SAN cell action potential with 1 μM ADO in (a) CTL and (b) HF (c) Change in action potential parameters from baseline (BL) in CTL and HF SAN cells. Action potentials parameters for CTL and HF grouped were compared via two-way repeated measures ANOVA. SDD was determined to have a significant interaction, and comparisons for this parameter were performed via paired t-test. SAN cells were isolated from 9 CTL dogs and 6 HF dogs.