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Adenosine generates GIRK-mediated IKAdo in HF SAN cells
(a) Representative raw current traces of IKAdo in CTL (left) and HF (right) SAN cells activated by 1 μM and 10 μM ADO. Current was elicited using a 1500 ms step protocol (above) and measured after digitally subtracting the paired untreated baseline for each cell (b) I-V relationship of IKado in HF activated by 1 μM and 10 μM ADO. SAN cells were isolated from 5 CTL dogs and 4 HF dogs.
