Table 2.
Genetic variant distributions of the long noncoding RNA growth arrest-specific transcript 5 (GAS5) in Taiwanese women with uterine cervical invasive cancer or precancerous lesions and normal controls.
| GAS5 genetic polymorphisms | Normal controls (n=307, %) | Pre- cancerous lesions (n =97, %) | Invasive cancer (n=111, %) | p values | AORs (95% CIs)a | Ad. p values | AORs (95% CIs)b | Ad. p values |
|---|---|---|---|---|---|---|---|---|
| rs145204276 | ||||||||
| Ins/Insc | 119, 38.8 % | 36, 37.1% | 47, 42.3% | 0.144 | 1.00 | 1.00 | ||
| Ins/Del | 138, 45.0 % | 54, 55.7% | 48, 43.2% | 1.29 (0.79-2.10) | 0.308 | 0.80 (0.48-1.33) | 0.387 | |
| Del/Del | 50, 16.3 % | 7, 7.2% | 16, 14.4% | 0.46 (0.19-1.11) | 0.085 | 0.75 (0.37-1.54) | 0.436 | |
| Ins/Insc | 119, 38.8 % | 36, 37.1% | 47, 42.3% | 0.718 | 1.00 | 1.00 | ||
| Ins/Del & Del/Del | 188, 61.2% | 61, 62.9% | 64, 57.7% | 1.07 (0.67-1.71) | 0.781 | 0.79 (0.49-1.26) | 0.321 | |
| Ins/Ins & Ins/Delc | 257, 83.7% | 90, 92.8% | 95, 85.6% | 0.082 | 1.00 | 1.00 | ||
| Del/Del | 50 16.3% | 7, 7.2% | 16, 14.4% | 0.40 (0.18-0.92) | 0.030 | 0.85 (0.43-1.65) | 0.624 | |
| rs55829688 | ||||||||
| TTc | 148, 50.2% | 45, 48.4% | 54, 51.4% | 0.747 | 1.00 | 1.00 | ||
| TC | 121, 41.0% | 40, 43.0% | 46, 43.8% | 1.08 (0.66-1.77) | 0.752 | 0.97 (0.59-1.59) | 0.896 | |
| CC | 26, 8.8% | 8, 8.6% | 5, 4.8% | 1.02 (0.43-2.41) | 0.964 | 0.63 (0.22-1.82) | 0.393 | |
| TTc | 148, 50.2% | 45, 48.4% | 54, 51.45 | 0.912 | 1.00 | 1.00 | ||
| TC/CC | 147, 49.8% | 48, 51.6% | 51, 48.6% | 1.07 (0.67-1.71) | 0.773 | 0.92 (0.57-1.48) | 0.719 | |
| TT/TCc | 269, 91.2% | 85, 91.4% | 100, 95.2% | 0.402 | 1.00 | 1.00 | ||
| CC | 26, 8.8% | 8, 8.6% | 5, 4.8% | 0.98 (0.43-2.26) | 0.970 | 0.64 (0.23-1.81) | 0.398 |
aAdjusted p values and AORs with their 95% CIs were defined using multinomial logistic regression model after controlling age between patients with cervical precancerous lesions and control women.
bAdjusted p values and AORs with their 95% CIs were defined using multinomial logistic regression model after controlling age between patients with cervical invasive cancer and control women.
cUsed as a reference for comparison to define the odds ratios of other genotypes.
AORs, adjusted odds ratios; 95% CIs, 95% confidence intervals; Ad. p, adjusted p; Ins, insertion, presence of AGGCA; Del, deletion, absence of AGGCA.