Table 3.
Associations of genetic variant distribution of long noncoding RNA growth arrest-specific transcript 5 (GAS5) with clinicopathological factors of the patients with uterine cervical invasive cancer.
| GAS5 rs145204276 | ||||
|---|---|---|---|---|
| Variablesa | Ins/Ins Ins/delb |
Del/del | p value | ORs (95% CIs) |
| Clinical stage N (%) | 0.332 | |||
| stage Ib | 53 (82.8) | 11 (17.2) | 1.00 | |
| ≥ stage II | 42 (89.4) | 5 (10.6) | 0.57 (0.19-1.78) | |
| Pathologic type N (%) | 0.683 | |||
| squamous cell carcinomab | 85 (85.9) | 14 (14.1) | 1.00 | |
| adenocarcinoma | 10 (83.3) | 2 (16.7) | 1.21 (0.24-6.14) | |
| Cell grading N (%) | 0.226 | |||
| well (grade 1)b | 11 (73.3) | 4 (26.7) | 1.00 | |
| moderate & poor (grades 2/3) | 84 (87.5) | 12 (12.5) | 0.39 (0.11-1.43) | |
| Stromal invasion depth N (%) | 0.550 | |||
| ≤10 mmb | 49 (83.1) | 10 (16.9) | 1.00 | |
| >10 mm | 41 (87.2) | 6 (12.8) | 0.72 (0.24-2.14) | |
| Tumor diameterb N (%) | 0.231 | |||
| ≤ 4cm | 50 (82.0) | 11 (18.0) | 1.00 | |
| >4cm | 45 (90.0) | 5 (10.0) | 0.51 (0.16-1.57) | |
| Parametrium N (%) | 0.089 | |||
| no invasionb | 56 (81.2) | 13 (18.8) | 1.00 | |
| invasion | 39 (92.9) | 3 (7.1) | 0.33 (0.09-1.24) | |
| Vagina N (%) | 0.610 | |||
| no invasionb | 59 (84.3) | 11 (15.7) | 1.00 | |
| invasion | 36 (87.8) | 5 (12.2) | 0.75 (0.24-2.32) | |
| Pelvic lymph node N (%) | 0.757 | |||
| no metastasisb | 71 (84.5) | 13 (15.5) | 1.00 | |
| metastasis | 24 (88.9) | 3 (11.1) | 0.68 (0.18-2.60) | |
Statistical analyses: chi-square or Fisher's exact tests
aSome clinicopathological data could not be obtained from the patients with cervical invasive cancer due to incomplete medical charts or records.
bAs a reference. ORs, odds ratios; 95% CIs, 95% confidence intervals; Ins, insertion, presence of AGGCA; Del, deletion, absence of AGGCA.