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. 2020 May 18;17(9):1257–1268. doi: 10.7150/ijms.44285

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Silencing ID1 reverses IL-1β stimulation-induced tumor cell stemness. ID1 was knocked down with siID1, while siNC was used as a negative control. (A and B) Silencing ID1 inhibits sphere formation capability induced by IL-1β stimulation in SCC7 cells (A) and B16-F10 cells (B). Representative images of sphere formation were displayed on the left. The sphere numbers were calculated and shown on the right. Silencing ID1 reverses IL-1β stimulation-induced upregulation of stemness genes, including ALDH, SOX2, OCT4 and Nanog in SCC7 cells (C) and B16-F10 cells (D).