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. 2020 May 15;16(12):2063–2071. doi: 10.7150/ijbs.45999

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Inhibition of PTTG1 mimics KLF10-induced biological effects on MM. (A) WB showed the effects of PTTG1 siRNA to knockdown PTTG1. PTTG1 knockdown promoted apoptosis (B) and inhibited cell proliferation (C) and cell cycle progression (D). (E) WB measured the cycle- and apoptosis-associated factors. (F) WB showed that PTTG1 knockdown suppressed β-catenin nuclear accumulation in MM cells. (G) WB revealed that PTTG1 knockdown suppressed GSK3β phosphorylation in MM cells. n = six repeats with similar results. *P<0.05, n.s=no significance.