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. 2020 Apr 27;16(12):2029–2041. doi: 10.7150/ijbs.45420

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The oxygen-sensing pathway connects DNA methylation and aerobic glycolysis. (a) The HIF complex can recruit P300 and CBP and then stimulate the HREs in the promoters of its target genes, promoting glycolysis-related gene expression. (b) CITED4 can competitively bind P300 and CBP, thereby inhibiting HIF's function. However, CITED4 is regulated by DNA methylation. (c) Wwox, which is regulated by DNA methylation, could disrupt HIF1-α's stability by affecting the PHD pathway. (d) LIMD1 acts as a scaffold to bind PHDs and VHL, which are key molecules for the degradation of HIF1-α. LIMD1 and VHL can be inhibited by DNA methylation.