Table 4.
Complications from included studies for systematic review 1 on HFNC for acute hypoxemic respiratory failure
| HFNC | Standard O2 | |
|---|---|---|
| Makdee, 201744 | n = 63 | n = 65 |
| Thoracic and cervical discomfort | 2 | 0 |
| Feeling hot | 4 | 0 |
| Jones, 201649 | n = 165 | n = 138 |
| Apnea | 0 | 1 |
| Drop in GCS of 2 or more points | 1 | 6 |
| Fall in GCS due to CO2 retention | 0 | 3 |
| Raeisi, 201942 | n = 20 | n = 20 |
| Device-induced heat | 2 | 0 |
| Nasal irritation | 2 | 0 |
| Refractory asthma/hypoxia | 0 | 1 |
| Rittayamai, 201551 | n = 20 | n = 20 |
| Unpleasant smell | 1 | 0 |
| Temperature too warm | 1 | 0 |
| Chest discomfort | 1 | 0 |
| Ruangsomboon, 201943 | n = 44 | n = 44 |
| Discomfort | 5 | 0 |
| Feeling hot | 2 | 0 |
| Could not tolerate HFNC | 1 | 0 |
| Frat, 201548 | n = 106 | n = 94 |
| Cardiac dysrhythmia | 11 | 16 |
| Septic shock | 19 | 26 |
| Cardio-respiratory arrest | 5 | 7 |
| Nosocomial pneumonia | 4 | 8 |
| Azoulay, 201846 | n = 388 | n = 388 |
| ICU-acquired infection | 39 | 41 |
Makdee 2017 included aspiration and nasal ulceration but no events occurred in either group
Jones 2016 included pneumothorax, subcutaneous emphysema, and nasal pressure sore but no events occurred in either group
Bell 2015 reported that no adverse events occurred in either group
ICU = intensive care unit; GCS = Glasgow Coma Scale; HFNC = high-flow nasal cannula