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rhRSPO1-generated TESI have intestinal epithelial stem cells, a muscular layer and neuronal ganglia (Immunofluorescence). Groups (lines): mouse native small intestine, mTESI PBS, mTESI rhRSPO1. Staining: GFP (green)/PCNA (red) (A–C), SMA (red)/E-cadherin (green) (D–F), Tuj-1 (red) (G–I), H&E (J–L). Scale bars correspond to 100 μm.
