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Schematic illustration showing the drug delivery process of ZTC-NMs. (A) The PCB-like zwitterion-modified nanomedicine shows high stability in blood circulation, resulting in efficient tumor accumulation through the EPR effect. (B) In tumor acidic microenvironment, the acid-induced zwitterionic-to-cationic surface charge conversion leads to enhanced cellular internalization of the nanomedicine. (C) The high level of intracellular GSH permits triggered drug release.
