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. 2020 May 17;10(15):6581–6598. doi: 10.7150/thno.45528

Figure 7.

Figure 7

In vivo therapeutic efficacy of EVs-Dox against stage III ovarian carcinoma. (A) T1WI and T2WI of healthy mouse and tumor-bearing mouse in the coronal plane. Arrows indicate metastatic regions. (B) Experimental procedure of tumor induction and therapeutic regimen. (C) The images of GFP-expressing tumor-bearing mice during five-week-treatments of various formulations. At baseline (week 0) all groups showed equal abdomen fluorescence indicative of equal tumor burden. By week 1 to 5, the tumor burden was reduced in the mice treated with MiV-Dox compared with controls. (D) Quantitative fluorescence intensity of GFP in tumor-bearing mice with or without any treatments for 5 weeks. (E) Kaplan-Meier survival curves and the median survival time of mouse models of metastatic ovarian cancer after various treatments (n = 6 per group). Treated group (T) - Control group (C) = difference between median survival (days) of T vs. C (TGD). (T - C)/C (%TGD). The data are shown as mean ± s.d., *** = p < 0.001 by one-way ANOVA test.