Figure 9.

SC144 delays tumor growth in syngeneic mouse models. (A) Growth curves of s.c. MOC2-E6/E7 tumor-bearing C57BL/6 mice daily treated with vehicle or SC144. PBS or SC144 were administered on day 3 post-tumor implantation. Results represent mean ± SEM (n=7 for each group). Comparisons were made using a generalized estimating equation model. (B) Tumors from each group were harvested and homogenized for RNA extraction. Quantitative PCR (qPCR) was performed for Ifng, Tnf, and Arg1 (n=5 for each group). Results represent mean ± SEM, qPCR was performed in triplicates. Growth curves of body weight of mice treated with vehicle, SC144 or CPX. The body weight of mice was recorded daily, there were no significant changes in body weights of mice in each group (n=5). (C) Images of bulk tumors from CT-26 tumor-bearing BALB/c mice in control, SC144 or CPX-treated group. Scale bar, 1 cm. (D) Growth curves of s.c. CT-26 tumor-bearing mice daily treated with vehicle, SC144 or CPX. (E) The tumor weight and the tumors volume on the final day in SC144 group was significantly lower than vehicle-control, while CPX group was not. Mice were euthanized and tumors were isolated and weighed. Statistical significance was calculated using Student's t-test. Error bars indicate mean ± SEM (standard error of mean). *p < 0.05, **p < 0.01.