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. 2020 May 20;10(15):6743–6757. doi: 10.7150/thno.43938

Figure 2.

Figure 2

Ultralow dose DPI suppresses inflammatory responses and ROS production. (A) Analysis of the indicated proteins in the colonic lamina propria of the DSS-induced colitis model. The colonic lysates were collected on day 15 after DSS challenge. Serum levels of IL-6 (B) and TNF-α (C) in the DSS-induced colitis model (n = 5 per group). Four hours after LPS injection, the serum levels of IL-6 (D) and TNF-α (E) were determined by ELISA (n = 7 per group). (F) Representative images of 8-OHdG staining in the colon of each group are shown (black arrow indicates the positive area (brown)). Bar = 100 µm. (G) The percentage of 8-OHdG positive cells/ visual field in the colonic tissues was enumerated using Image-Pro Plus 5.0. Three fields per mouse were scored. *P < 0.05, **P < 0.01.