Figure 5.

An ultralow dose of DPI prevents the formation and development of CAC. (A) Mode pattern of the AOM/ DSS-induced CAC model. (B)Representative photographs of murine colons. (C) Number of tumors per mouse. (D) Tumor size, (E) tumor load, and (F) tumor distribution were measured for each group. (G) H&E staining of tumor morphology (Bar = 100 µm). n = 10 per group. (H) Analysis of the indicated proteins in the colonic intestinal epithelial cells. The experiment was repeated three times. Differences were calculated using a two-tailed Student's t-test. *P < 0.05, **P < 0.01.