TABLE 2.

The 4 most significant metabolites associated with OSDI among 20 significant metabolites adjusted for age, sex, and HbA1c levels.

Metabolite	OR	CL	CU	t value	P	FDR
Thiodiacetic acid*	1.55247681	1.26158984	1.9104341	4.15516541	3.25E-05	0.0006501
Uridine*	1.40832563	1.14309313	1.73510018	3.21621402	0.00129894	0.01298939
Octadecanamide*	1.3405631	1.09814985	1.63648834	2.8800132	0.00397659	0.02651057
Phthalic anhydride*	0.81766755	0.67425718	0.99158043	−2.0459358	0.04076269	0.20381346
3-Acrylamidopropyl trimethylammonium	1.19362223	0.98364445	1.44842379	1.79294729	0.07298135	0.28723142
Triglyme	1.65924095	0.9305183	2.95865276	1.71595966	0.08616943	0.28723142
N-Heptane	1.19858444	0.95035917	1.51164392	1.5299583	0.12602705	0.36007729
1-Piperidinecarboxaldehyde	1.14944952	0.94898168	1.39226524	1.42445336	0.15431528	0.37131023
2-Methylbutyroylcarnitine	1.14444901	0.94508279	1.38587174	1.38161611	0.1670896	0.37131023
Palmitic amide	0.88257065	0.72651124	1.07215266	−1.2582488	0.20830179	0.41660359
Diglyme	0.92001999	0.75985836	1.11394022	−0.8542429	0.39297044	0.68896788
N-(3-Indolylac etyl)-L-isol eucine	1.08241214	0.89532492	1.30859312	0.81795877	0.41338073	0.68896788
N,N′-Dicyclohexylurea	0.94679681	0.77986533	1.14946027	−0.5524484	0.58064115	0.82684503
(S)-Desoxy-D2PM	1.05012842	0.86620605	1.27310321	0.49790162	0.61855338	0.82684503
Tuckolide	0.95474254	0.78708046	1.1581196	−0.4700638	0.63830943	0.82684503
Alanyl-Alanine	0.95900176	0.79513398	1.15664076	−0.4378762	0.66147602	0.82684503
Dihydroterrein	0.96411129	0.79540346	1.16860262	−0.3724069	0.70958995	0.83481171
Indoline	1.02916604	0.84773779	1.24942257	0.2905526	0.77139351	0.8571039
N-methyl corydaldine	1.00723376	0.82432556	1.23072714	0.07049554	0.94379925	0.98564298
(-)-Corey Lactone Diol	0.99823666	0.82365976	1.20981561	−0.0179948	0.98564298	0.98564298

OSDI, Ocular Surface Disease Index; HbA1c, hemoglobin A1c; OR, odds ratio; CL, lower of confidence interval; CU, upper of confidence interval. * P < 0.05.