TABLE 3.
The 42 most significant metabolites associated with FBUT out of 57 significant metabolites adjusted of age, sex, and HbA1c level.
| Metabolite | OR | CL | CU | t value | P | FDR |
| Gamma-Aminobutyric acid* | 2.31000409 | 1.72405625 | 3.09509559 | 5.60895326 | 2.04E-08 | 1.16E-06 |
| L-Tyrosine* | 2.85341036 | 1.92114399 | 4.23807415 | 5.19494456 | 2.05E-07 | 5.84E-06 |
| Oxidized glutathione* | 1.7939313 | 1.42065818 | 2.26528066 | 4.90996828 | 9.11E-07 | 1.73E-05 |
| Cholesterol* | 1.73958267 | 1.38364581 | 2.18708274 | 4.74020998 | 2.13E-06 | 3.04E-05 |
| Glutamate* | 1.61563596 | 1.31307235 | 1.98791755 | 4.53449486 | 5.77E-06 | 6.58E-05 |
| fumarate* | 0.64862127 | 0.52991355 | 0.79392111 | –4.1976691 | 2.70E-05 | 0.00025619 |
| Butyrylcarnitine* | 1.70194948 | 1.32064315 | 2.19334955 | 4.10902868 | 3.97E-05 | 0.00032354 |
| Lactate* | 0.65144643 | 0.52930406 | 0.80177441 | –4.04551 | 5.22E-05 | 0.00037199 |
| Formate* | 0.66830153 | 0.54536283 | 0.81895375 | –3.8856717 | 0.00010205 | 0.00062014 |
| acetylcholine* | 0.65827145 | 0.53212825 | 0.81431741 | –3.8524858 | 0.00011692 | 0.00062014 |
| L-Isoleucine* | 1.47248491 | 1.2089998 | 1.79339303 | 3.84678675 | 0.00011968 | 0.00062014 |
| Oleamide* | 0.66041693 | 0.53217629 | 0.81956023 | –3.7664914 | 0.00016556 | 0.0007516 |
| 1-Stearoyl-2-Arachidonoyl PC* | 1.4633179 | 1.19916256 | 1.78566222 | 3.74810872 | 0.00017817 | 0.0007516 |
| Inosine* | 2.65048162 | 1.59011429 | 4.41795465 | 3.73920617 | 0.0001846 | 0.0007516 |
| Uracil* | 1.46024988 | 1.19506913 | 1.7842731 | 3.70288298 | 0.00021316 | 0.00081002 |
| Uridine* | 1.47168572 | 1.19767109 | 1.80839204 | 3.67598012 | 0.00023694 | 0.00084409 |
| Guanine* | 1.50029386 | 1.20718859 | 1.86456506 | 3.65785151 | 0.00025434 | 0.00085278 |
| L-Valine* | 1.4420049 | 1.18277435 | 1.75805143 | 3.62023335 | 0.00029434 | 0.00090405 |
| Dibutyl phthalate* | 0.67430255 | 0.54455312 | 0.83496708 | –3.6141379 | 0.00030135 | 0.00090405 |
| L-Methionine* | 1.47026597 | 1.18226511 | 1.8284241 | 3.46527672 | 0.00052969 | 0.00150961 |
| Uracil* | 1.42469938 | 1.15975359 | 1.75017206 | 3.37182114 | 0.00074673 | 0.00202684 |
| Cytosine* | 0.69994564 | 0.56654428 | 0.86475836 | –3.306898 | 0.00094335 | 0.00244414 |
| Uridine* | 1.40832563 | 1.14309313 | 1.73510018 | 3.21621402 | 0.00129894 | 0.00321911 |
| Squalene* | 1.37339911 | 1.12939739 | 1.67011642 | 3.17930202 | 0.0014763 | 0.00350622 |
| L-Kynurenine* | 0.72719546 | 0.59496403 | 0.88881547 | –3.111087 | 0.001864 | 0.00417575 |
| malate* | 0.72901762 | 0.59715129 | 0.89000341 | –3.1046987 | 0.00190473 | 0.00417575 |
| Spermine* | 1.35525764 | 1.11347072 | 1.64954788 | 3.03203154 | 0.00242914 | 0.00512818 |
| Citric acid* | 0.73919799 | 0.60698117 | 0.90021518 | –3.0055174 | 0.00265129 | 0.00539728 |
| L-Serine* | 1.42722391 | 1.12895219 | 1.80429969 | 2.97402045 | 0.00293925 | 0.00577716 |
| Glucose* | 0.73965682 | 0.60485591 | 0.90450007 | –2.9378068 | 0.00330543 | 0.00628032 |
| Pyroglutamic acid* | 1.32121764 | 1.08651926 | 1.60661307 | 2.79159771 | 0.00524485 | 0.00964376 |
| pyruvic acid* | 0.75616671 | 0.61730273 | 0.92626852 | –2.6998564 | 0.00693694 | 0.01231244 |
| Adenine* | 1.3194087 | 1.07818635 | 1.61459967 | 2.69079233 | 0.00712826 | 0.01231244 |
| Glycocholic acid* | 0.76903499 | 0.63133985 | 0.93676141 | –2.6089881 | 0.00908104 | 0.0152241 |
| L-Phenylalanine* | 0.77952238 | 0.64158301 | 0.9471185 | –2.506818 | 0.01218234 | 0.01983981 |
| Alpha-dimorphecolic acid* | 0.76942166 | 0.62336711 | 0.94969671 | –2.4405653 | 0.0146643 | 0.02321847 |
| Arginine* | 0.78958675 | 0.64748007 | 0.96288251 | –2.3336225 | 0.0196155 | 0.03021847 |
| creatine* | 0.79935316 | 0.6602648 | 0.96774124 | –2.2962044 | 0.0216642 | 0.03249629 |
| glycine* | 1.24311063 | 1.02397819 | 1.50913765 | 2.19949186 | 0.02784297 | 0.04069357 |
| Choline* | 0.80593633 | 0.66141539 | 0.98203547 | –2.13979 | 0.03237174 | 0.0455426 |
| Niacinamide* | 0.80940226 | 0.66658792 | 0.9828141 | –2.1350282 | 0.03275871 | 0.0455426 |
| 4-Hydroxycitrulline* | 1.24092841 | 1.01274466 | 1.52052476 | 2.08215659 | 0.03732817 | 0.05065966 |
| PS(20:2(11Z,14Z)/16:0) | 1.21081356 | 0.99481789 | 1.47370639 | 1.90817319 | 0.05636884 | 0.0745487 |
| S-Glutathionyl-L-cysteine | 0.82193434 | 0.67134384 | 1.0063041 | –1.8991378 | 0.05754637 | 0.0745487 |
| PS(22:4(7Z,10Z,13Z,16Z)/17:0) | 1.2217118 | 0.96398133 | 1.5483492 | 1.65654564 | 0.09761137 | 0.12364107 |
| Oleoyl Oxazolopyridine | 0.85018063 | 0.69683413 | 1.03727281 | –1.5993885 | 0.10973431 | 0.13597512 |
| Triisobutyl phosphate | 0.85487102 | 0.70210055 | 1.04088291 | –1.5610858 | 0.11850352 | 0.14371703 |
| 2′-Hydroxy-a-naphthoflavone | 0.84884908 | 0.68885126 | 1.04600922 | –1.5378668 | 0.12408118 | 0.14529034 |
| 1-Oleoyl-2-acetyl-sn-glycerol | 0.86144308 | 0.7120229 | 1.04221953 | –1.5345325 | 0.12489871 | 0.14529034 |
| 1,2-Dierucoyl-SN-Glycero-3-Phosphoethanolamine | 0.86269924 | 0.71131474 | 1.04630193 | –1.5002282 | 0.13355529 | 0.15225303 |
| S-Acetyldihydrolipoamide-E | 0.86465346 | 0.71188448 | 1.05020635 | –1.4661349 | 0.14261154 | 0.15938937 |
| Tetrahydropteroyltri-L-glutamate | 1.14762768 | 0.94841889 | 1.3886789 | 1.41556554 | 0.15690275 | 0.17047874 |
| Streptidine 6-phosphate | 0.87080284 | 0.71847067 | 1.05543292 | –1.4100825 | 0.15851532 | 0.17047874 |
| Succinoadenosine | 1.1382523 | 0.93749381 | 1.38200198 | 1.30802614 | 0.19086444 | 0.20146802 |
| PE(16:0/0:0) | 0.88503301 | 0.71933451 | 1.08890011 | –1.1547383 | 0.2481976 | 0.25722297 |
| MG(8:2(9Z,12Z)/0:0/0:0) | 0.92122998 | 0.75599324 | 1.12258236 | –0.8134942 | 0.41593479 | 0.4233622 |
| Tributyl phosphate | 0.95282779 | 0.77633407 | 1.16944605 | –0.4623322 | 0.64384309 | 0.64384309 |
OR, odds ratio; CL, lower of confidence interval; CU, upper of confidence interval; *p<0.05.