TABLE 6.

The increasing and decreasing metabolites in groups A–F.

Group A ≦ 50 Control (n = 10), Dry Eye (n = 15)		Group B > 50 Control (n = 18), Dry Eye (n = 70)		Group C ≦ 5 Control (n = 16), Dry Eye (n = 42)		Group D > 55 Control (n = 12), Dry Eye (n = 43)		Group E ≦ 60 Control (n = 121), Dry Eye (n = 40)		Group F > 60 Control (n = 7), Dry Eye (n = 45)
Increased	Decreased	Increased	Decreased	Increased	Decreased	Increased	Decreased	Increased	Decreased	Increased	Decreased
Acetylcholine	Adenine	Acetylcholine	[8]-shogaol	Citric acid	[8]-shogaol	Acetylcholine	[8]-shogaol	Acetylcholine	[8]-shogaol	Acetylcholine	[8]-shogaol
Alpha-dimorphecolic acid	Amino-n-butyrate	Alpha-dimorphecolic acid	Adenine	Creatine	Adenine	Citric acid	Adenine	Alpha-dimorphecolic acid	Adenine	Alpha-dimorphecolic acid	Adenine
Citric acid	Cholesterol	Citric acid	Amino-n-butyrate	Cystosine	Amino-n-butyrate	Creatine	Amino-n-butyrate	Citric acid	Amino-n-butyrate	Citric acid	Amino-n-butyrate
Cystosine	Glutamate	Creatine	Betaine	Dibutyl Phthalate	Betaine	Cystosine	Betaine	Creatine	Betaine	Cystosine	Betaine
Dibutyl Phthalate	Glycine	Cystosine	Butyrylcamitine	Fumarate	Butyrylcamitine	Dibutyl Phthalate	Butyrylcamitine	Cystosine	Butyrylcamitine	Dibutyl Phthalate	Butyrylcamitine
Formate	Hypoxanthine	Dibutyl Phthalate	Cholesterol	Glucose	Gamma-Aminobutyric acid	Fumarate	Cholesterol	Dibutyl Phthalate	Cholesterol	Fumarate	Cholesterol
Fumarate	Inosine	Formate	Gamma-Aminobutyric acid	Lactate	Glutamate	Glucose	Glutamate	Formate	Gamma-Aminobutyric acid	Glucose	Gamma-Aminobutyric acid
Glucose	Lithocholic acid	Fumarate	Glutamate	L-Kynurenine	Guanine	Lactate	Guanine	Fumarate	Glutamate	Lactate	Glutamate
Lactate	L-Methionine	Glucose	Glycine	L-Phenyl alanine	Hypoxanthine	L-Kynurenine	Hypoxanthine	Glucose	Glycine	L-Phenyl alanine	Hypoxanthine
L-Phenyl alanine	L-tyrosine	Lactate	Guanine	L-Proline	Inosine	L-Phenyl alanine	Inosine	Lactate	Guanine	L-Proline	Inosine
Malate	Oxidized glutathione	L-Kynurenine	Hypoxanthine	Malate	L-Isoleucine	L-Proline	L-Isoleucine	L-Kynurenine	Hypoxanthine	Malate	L-Isoleucine
Oleamide	Purine	L-Phenyl alanine	Inosine	Oleamide	Lithocholic acid	L-Serine	Lithocholic acid	L-Phenyl alanine	Inosine	Niacinamide	Lithocholic acid
Pyruvic acid	Pyroglutamic acid	L-Proline	L-Isoleucine		L-Methionine	Malate	L-Tryptophan	L-Proline	L-Isoleucine	Oleamide	L-Tyrosine
	Pyrrolidonc carboxylic acid	Malate	Lithocholic acid		L-Serine	Niacinamide	L-Tyrosine	Malate	Lithocholic acid	Pyruvic acid	L-Valine
	Spermine	Niacinamide	L-Methionine		L-Tryptophan	Oleamide	L-Valine	Niacinamide	L-Methionine		N-Acetylglu cosamine
	Squalene	Oleamide	L-serine		L-Tyrosine	Pyruvic acid	N-Acetylglu cosamine	Oleamide	L-Serine		Octadecanamide
	Urocanic acid	Pyruvic acid	L-Tryptophan		L-Valine		Octadecanamide	Pyruvic acid	L-Tryptophan		Oxidized glutathione
			L-Tyrosine		N-Acetylglu cosamine		Oxidized glutathione		L-Tyrosine		Pyrrolidonc carboxylic acid
			L-Valine		Octadecanamide		Purine		L-Valine		Spermine
			N-Acetylglu cosamine		Oxidized glutathione		Pyroglutamic acid		N-Acetylglu cosamine		Squalene
			octadecanamide		Purine		Spermine		Octadecanamide		Thiodiacetic acid
			Oxidized glutathione		Pyroglutamic acid		Squalene		Oxidized glutathione		Uracil
			Purine		Pyrrolidonc carboxylic acid		Thiodiacetic acid		Purine		Uridine
			Pyroglutamic acid		Spermine		Uracil		Pyroglutamic acid		Urocanic acid
			Pyrrolidonc carboxylic acid		Squalene		Uridine		Pyrrolidonc carboxylic acid
			Spermine		Thiodiacetic acid		Urocanic acid		Spermine
			Squalene		Uracil				Squalene
			Thiodiacetic acid		Uridine				Thiodiacetic acid
			Uracil		Urocanic acid				Uracil
			Uridine						Uridine
			Urocanic acid						Urocanic acid

Group A age: ≤50 years, group B age: >50 years, group C age: ≤55 years, group D age: >55 years, group E age: ≤60 years, group F age: >60 years.