Figure.

Contour plot of the interaction between plasma βARK1 and SHFM score in explaining physical symptoms measured by the HFSPS. The plot shows that HFSPS scores are dependent on both βARK1 and SHFM scores, but the range of HFSPS scores more closely follows the gradient of βARK1 levels than the gradient of SHFM scores. For example, those with the worst physical symptoms (black) have higher levels of βARK1 but better SHFM scores. Conversely, those with the least physical symptoms (white) have worse SHFM scores and relatively low plasma βARK1. Abbreviations: βARK1, β-adrenergic receptor kinase-1; HFSPS, Heart Failure Somatic Perception Scale; SHFM, Seattle Heart Failure Model.