Fig. 7.

Model of ΔFosB accumulation and self-assembly. The ΔFosB protein accumulates in specific regions of the brain upon exposure to chronic insult such as drugs of abuse, stress, or seizures. Once a cellular threshold level of ΔFosB protein is reached, swamping ambient concentrations of JunD, self-assembly occurs generating several non-canonical molecular arrangements. The functional impact of these species must now be elucidated. For clarity, the disordered regions are not portrayed.