Table 1.
Characteristics of 90+ Study Participants Included in The Study*
| Characteristic | Normal Cognition (N = 7) | CIND (N = 5) | Demented (N = 20) | Total (N = 32) |
|---|---|---|---|---|
| Mean (Range) | ||||
| Age at Death (yrs) | 95.7 (93 – 99) | 96.4 (94 – 100) | 96.1 (92 – 105) | 96.1 (92 – 105) |
| Brain weight (g) | 1225.1 (1127 – 1390) | 1105.4 (921 – 1253) | 1088.1 (871 – 1290) | 1120.8 (871 – 1390) |
| PMI (hrs) | 4.5 (2.2 – 7.0) | 4.7 (3.8 – 6.0) | 4.1 (2 – 7) | 4.3 (2 – 7) |
| BBNFT (stage) | 3.0 (2 – 4) | 2.8 (1 – 4) | 4.3 (2 – 6) | 3.8 (1 – 6) |
| BBSP (stage) † | 0.9 (0 – 2) | 1.8 (1 – 2) | 1.5 (0 – 3) | 1.4 (0 – 3) |
| MMSE | 26.0 (21 – 29) | 26.0 (21 – 29) | 14.3 (0 – 27) | 18.9 (0 – 29) |
| Interval from exam to death (months) | 8.3 (2.8 – 12.9) | 7.6 (3.5 – 12.3) | 6.8 (1.7 – 16.1) | 7.2 (1.7 – 16.1) |
| SYN (% of GAPDH) | 106.0 (51.2 – 177.5) | 177.7 (117.7 – 241.5) | 72.3 (0 – 194.2) | 96.1 (0.0 – 241.5) |
| PSD-95 (% of GAPDH) | 24.9 (2.4 – 71.2) | 17.4 (0.0 – 54.7) | 26.8 (0.0 – 79.0) | 24.9 (0.0 – 79.0) |
| GAP-43 (% of GAPDH) | 98.3 (59.3 – 147.5) | 124.6 (52.6 – 258.8) | 71.8 (27.2 – 156.6) | 85.8 (27.2 – 258.8) |
| Number (%) | ||||
| Female (%) | 4 (57) | 4 (80) | 16 (80) | 24 (75) |
| Education (%) | ||||
| less than college | 1 (14) | 2 (40) | 7 (35) | 10 (31) |
| college or higher | 6 (86) | 3 (60) | 13 (65) | 22 (69) |
*
CIND = Cognitively impaired not demented
PMI = Post-mortem interval; BBNFT = Braak & Braak neurofibrillary tangle; BBSP = Braak & Braak senile plaque; MMSE = Mini-mental state exam; SYN = synaptophysin; PSD = post synaptic density; GAP = growth associated protein
†
Average BBSP stage was obtained by assigning a numerical score to each stage as follows: 0=0, A=1, B=2, C=3.